Posted in The Role of the Immune System

The Link Between Diet and Immune Resilience

Essential Macronutrients for Immune Health

Maintaining a strong and resilient immune system is crucial for overall health and well-being. The roles of various vitamins and minerals in supporting immune function are widely recognized. However, the importance of essential macronutrients is often overlooked. Proteins, carbohydrates, and fats are the body’s fundamental building blocks. They play a vital role in ensuring that the immune system functions optimally.

Proteins are essential for the production and regulation of immune cells. They are also crucial for creating antibodies that help fight off infections. Different types of proteins provide the necessary amino acids. These proteins are found in lean meats, fish, eggs, and legumes. They enable the body to mount an effective immune response.

Carbohydrates serve as the primary energy source for immune cells, allowing them to carry out their crucial functions. Complex carbohydrates are especially beneficial. They are found particularly in whole grains, fruits, and vegetables. These carbohydrates provide a steady supply of energy. They also support overall metabolic health.

Fats, often overlooked in discussions about immune health, are also essential macronutrients. Certain types of fats have anti-inflammatory properties. Omega-3 fatty acids are particularly beneficial in fatty fish, flaxseeds, and walnuts. These fats help regulate the inflammatory response, which is a key component of the immune system’s defense mechanisms. Omega-3 fatty acids reduce inflammation. This reduction can help prevent the overactivation of the immune system. Overactivation can lead to chronic conditions.

The optimal balance and intake of these essential macronutrients vary depending on individual needs. They also depend on activity levels and overall health status. A well-rounded, nutrient-dense diet incorporates a variety of protein sources. It includes complex carbohydrates and healthy fats. This type of diet can help support a strong and resilient immune system.

Antioxidants and Immune Function

The immune system is constantly exposed to a variety of stressors. These stressors are both internal and external. They can lead to the production of harmful free radicals and oxidative stress. Antioxidants are compounds that neutralize these free radicals. They play a vital role in supporting the immune system. Antioxidants also maintain overall health.

One of the primary ways antioxidants support the immune system is by reducing inflammation. Chronic inflammation can weaken the immune system, making it more susceptible to infections and chronic diseases. Antioxidants include vitamins C and E, carotenoids, and polyphenols. They help reduce inflammation. These compounds work by neutralizing the free radicals that contribute to the inflammatory response.

Additionally, antioxidants protect immune cells from damage and enhance their function. For example, vitamin C is vital for the production of white blood cells. These cells are the primary defenders against infections. Selenium is a trace mineral with antioxidant properties. It is crucial for the proper functioning of the thymus gland. This gland is responsible for maturing and regulating T cells, which are key components of the adaptive immune system.

Furthermore, antioxidants can boost the immune system’s ability to respond to threats. Antioxidants reduce oxidative stress. They support overall immune health. This enhances the body’s capability to mount an effective response to pathogens such as viruses and bacteria.

The optimal intake of antioxidants can vary based on individual factors. These include age, health status, and lifestyle. A diverse, nutrient-rich diet includes a variety of antioxidant-rich foods. These foods consist of fruits, vegetables, nuts, and whole grains. Such a diet can help ensure the body has the necessary resources. These resources support a strong and resilient immune system.

Vitamins and Minerals for Immune Support

In addition to essential macronutrients and antioxidants, vitamins and minerals play a crucial role in supporting the immune system. These micronutrients are involved in various processes that enhance the body’s ability to fight off infections and maintain overall health.

Vitamin C is one of the most well-known nutrients for immune health. It is vital for the proper functioning of the immune system. It includes the production and activity of white blood cells. It enhances the skin’s barrier function. It also regulates the inflammatory response. Additionally, Vitamin C is a powerful antioxidant that helps neutralize harmful free radicals and reduce oxidative stress.

Vitamin D, often referred to as the “sunshine vitamin,” is also critical for immune function. It helps regulate the immune system by supporting the production of antimicrobial proteins and enhancing the activity of immune cells. A deficiency in Vitamin D increases the risk of infections. It is essential to ensure adequate intake through dietary sources, supplements, or sun exposure.

Zinc is another essential mineral that supports the immune system. It is necessary for the development and function of immune cells and the production of antibodies. Zinc also aids in wound healing. It helps maintain the skin’s barrier function. This barrier acts as a key line of defense against pathogens.

Selenium, a trace mineral with antioxidant properties, supports the proper functioning of the thymus gland and the immune system. Iron is crucial for producing hemoglobin, which carries oxygen to the body’s tissues, including immune cells.

To support a strong and resilient immune system, you need a balanced intake of these vital vitamins and minerals. This should be done through a varied, nutrient-rich diet. In some cases, supplements may be necessary to address specific deficiencies or to support overall immune health. However, it is always best to consult with a healthcare professional before making any changes to your dietary regimen.

Selenium is a trace mineral with antioxidant properties. It supports the proper functioning of the thymus gland and the immune system. Iron, on the other hand, is crucial for producing hemoglobin. Hemoglobin carries oxygen to the body’s tissues, including the immune cells. It is important to maintain a balanced intake of these essential vitamins and minerals. A varied, nutrient-rich diet helps support a strong and resilient immune system. In some cases, supplements may be necessary to address specific deficiencies or support overall immune health. Still, it is always best to consult with a healthcare professional before making any changes to your dietary regimen.

Posted in Autoimmune the dis-EASE, The Role of the Immune System

Boost Your Immune System: An Integrative Approach

Integrative Approaches to Immune Improvement

Lifestyle choices and specific nutritional interventions are crucial in supporting the immune system. Holistic and integrative approaches offer a more comprehensive strategy for enhancing immunity. This post will explore how combining different techniques can strengthen the body’s natural defenses.

Mind-Body Practices and Immune Role

Many studies have shown that mind-body practices, like meditation, mindfulness, and tai chi, can positively affect the immune system. These practices help reduce stress and inflammation, both essential for maintaining a healthy immune response. By incorporating mind-body techniques into our daily routines, we can use the mind-body connection to improve our overall immune health.

The Role of Physical Activity

Regular physical activity benefits our overall health and plays a crucial role in supporting the immune system. Moderate exercise enhances the circulation of immune cells, improves their performance, and reduces inflammation. But, finding a balance is important, as excessive or intense exercise can temporarily suppress the immune system. Engaging in different physical activities is beneficial. Aerobic exercise and strength training can maximize the immune-boosting benefits of an active lifestyle.

Integrative Therapies and Immune Resilience

Along with lifestyle choices and nutritional support, various integrative therapies can enhance immune performance. Acupuncture is a practice rooted in traditional Chinese medicine. It is used to help regulate the immune system. It also improves resistance to illness. Similarly, massage therapy has been linked to enhanced immune role. This is likely due to its ability to reduce stress and promote relaxation. Individuals can combine these integrative approaches with other strategies. These strategies support immune health. Through this combination, individuals can create a comprehensive plan to boost their immune resilience. Additionally, it enhances their overall well-being.

Posted in How Lifestyle Choices Affect Immune Function, Understanding Autoimmune dis-EASE

How Lifestyle Choices Affect Immune Function

The human immune system is a complex network of cells, tissues, and organs. It protects the body from pathogens like viruses, bacteria, and parasites. Maintaining balance within this system is essential for overall health. An optimally functioning immune system can recognize and eliminate threats while preventing excessive inflammation and autoimmune responses.

Regulating the inflammatory response is crucial, as inflammation helps fight infections and heal injuries. However, chronic inflammation can lead to health issues such as autoimmune disorders and cardiovascular disease. Mechanisms like anti-inflammatory cytokines and regulatory T cells help keep this response in check.

Additionally, immune cells, including T cells, B cells, and natural killer cells, must work together harmoniously. Disruptions in their balance can result in autoimmune diseases or immunodeficiencies.

A healthy lifestyle, including a balanced diet, regular exercise, and stress management, significantly supports immune regulation. Nutrients like antioxidants, omega-3 fatty acids, and probiotics can enhance immune function. Physical activity boosts immune cell circulation. It also reduces inflammation.

In summary, maintaining a balanced immune system is vital for health. Understanding these mechanisms allows individuals to make proactive lifestyle choices to support their immune function.

Factors Influencing Immune Regulation

Various internal and external factors influence the immune system’s regulation and balance. These factors are vital for maintaining its health and function.

Genetics plays a key role. Variations can affect immune-related genes, predispose individuals to disorders, and alter responses to infections and therapies. Additionally, epigenetic modifications, like DNA methylation, influence immune role.

Age is another important factor. As individuals age, a process called immunosenescence occurs, characterized by decreased immune cell function and diversity. This leads to increased susceptibility to infections, lower vaccine efficacy, and a higher risk of chronic inflammation.

Environmental factors include exposure to pollutants and pathogens. These can trigger inflammatory responses and disrupt immune balance. This increases the risk of autoimmune diseases.

Lifestyle choices, like diet, exercise, and stress management, significantly impact immune regulation. A balanced diet provides essential nutrients, while regular physical activity enhances immune function. In contrast, chronic stress can disrupt immune responses and increase inflammation.

Understanding these interrelated factors is crucial for developing personalized strategies to support a healthy immune system. Tailored interventions can help individuals keep immune health and overall well-being.

Strategies for Immune System Optimization

Optimizing the immune system is a multifaceted task that requires a comprehensive approach involving various strategies and interventions. Here are some key strategies to help individuals maintain a well-regulated and balanced immune system:

1. **Dietary Modifications:**

   – Consume a nutrient-rich, balanced diet that includes a variety of fruits, vegetables, whole grains, lean proteins, and healthy fats.

   – Include immune-boosting foods in your diet. Examples are citrus fruits, leafy greens, nuts, and fatty fish. These foods are rich in vitamins, minerals, and antioxidants.

   – Maintain a healthy gut microbiome by eating probiotic-rich foods or taking probiotic supplements.

2. **Physical Activity and Exercise:**

   – Engage in regular physical activity, like aerobic exercise, strength training, and mind-body practices like yoga and Tai Chi.

   – Exercise enhances immune function by improving circulation, reducing inflammation, and promoting the activity of immune cells.

3. **Stress Management:**

   – Practice stress-reducing techniques, like meditation, deep breathing exercises, and mindfulness-based practices.

   – Engage in activities that promote relaxation and mental well-being. Spend leisure time in nature, practice hobbies, or connect with loved ones.

4. **Adequate Sleep and Rest:**

   – Prioritize getting sufficient, high-quality sleep. It plays a critical role in the regulation and function of the immune system.

   – Establish a consistent sleep routine and create an environment conducive to sleep.

5. **Vaccination and Immunization:**

   – Stay up-to-date with recommended vaccinations to enhance the immune system’s ability to respond to specific pathogens.

   – Consult with healthcare professionals to ensure appropriate vaccination schedules and consider any necessary booster shots.

6. **Supplementation (if necessary):**

   – In some cases, certain dietary supplements—like vitamins, minerals, or herbal extracts—may support immune function.

   – Always consult a healthcare professional before starting any supplement regimen to ensure safety and efficacy.

7. **Mental Well-being:**

   Focus on stress management techniques. These include mindfulness, meditation, and relaxation practices. It is important since chronic stress can negatively impact the immune system.

   – Keep a positive mental outlook and engage in activities that promote well-being.

By implementing a combination of these strategies, individuals can actively work towards optimizing their immune system. This promotes overall health. It also enhances resilience in the face of various health challenges.

Posted in Understanding the Inflammatory Response: Acute vs. Chronic

Understanding the Inflammatory Response: Acute vs. Chronic

The Inflammatory Response

The body’s inflammatory response is a crucial defense mechanism. It protects against harmful stimuli like pathogens, damaged cells, or irritants. This complex biological process involves a series of coordinated events designed to isolate and eliminate the source of the problem. These events also promote healing.

The inflammatory response starts when the immune system detects a threat. This threat can result from various factors, including foreign substances, physical injuries, or autoimmune disorders. Once a threat is identified, the body increases blood flow to the affected area rapidly. This causes redness, swelling, and heat. This response releases several chemical mediators, including histamine, prostaglandins, and leukotrienes, which further amplify the inflammatory response.

Specialized immune cells, including neutrophils and macrophages, are recruited in the inflammatory response. They are brought to the site of injury or infection and are essential for removing the source of inflammation. They do this by attacking and destroying it directly. Alternatively, they initiate a cascade of events that leads to its removal. This process may involve the release of enzymes. Reactive oxygen species also help break down and remove the harmful agent.

As the inflammatory response progresses, the body begins to repair the damaged tissue. This repair process includes the formation of new blood vessels. It also involves the deposition of collagen and other structural proteins. Additionally, there is a proliferation of cells to replace those that were lost or damaged. In cases of acute inflammation, the process is usually rapid. It allows the body to restore the affected area to its normal state within days or weeks.

However, in some instances, the inflammatory response can become chronic. This can result in long-term damage. It may lead to the development of various health problems. Chronic inflammation has been linked to a wide range of diseases, including cardiovascular disease, cancer, and autoimmune disorders. Understanding the mechanisms and causes of chronic inflammation is an active area of research. Scientists are working to develop new therapies and interventions. They aim to address this significant public health challenge.

Acute vs. Chronic Inflammation

The inflammatory response can be divided into two main types: acute inflammation and chronic inflammation.

**Acute inflammation** is the body’s immediate and short-term reaction to harmful stimuli, such as injuries or infections. This response is characterized by its rapid intensity, as the body mobilizes its defenses to quickly address the issue. Common symptoms of acute inflammation include redness, swelling, heat, and pain. These symptoms arise from increased blood flow and the release of inflammatory mediators to the affected area. Acute inflammation plays a crucial role in the healing process. It isolates and eliminates the source of harm. It also initiates tissue repair. In many cases, it resolves on its own. The body can resolve the issue and restore normal function within days or weeks.

In contrast, **chronic inflammation** is a long-term and persistent response that can last for months or even years. This type of inflammation is often linked to underlying health conditions. These include autoimmune disorders, chronic infections, or ongoing exposure to irritants. Chronic inflammation can subtly affect the body. It can lead to gradual tissue deterioration. This process results in the development of various health problems. Symptoms of chronic inflammation may include fatigue and joint pain. Digestive issues might also occur. There is an increased risk of chronic diseases such as heart disease, cancer, and Alzheimer’s disease. Unlike acute inflammation, chronic inflammation is not self-limiting. It typically requires targeted interventions such as medications, lifestyle changes, or management of the underlying condition. These actions help bring it under control.

Understanding the differences between acute and chronic inflammation is essential for effectively diagnosing and treating various health conditions. Healthcare providers can recognize the signs and symptoms of each type of inflammation. This helps them develop appropriate strategies to address the root cause of the problem. It also improves patient outcomes.

Inflammation and Autoimmune Diseases

Autoimmune diseases are a group of disorders. The immune system mistakenly attacks the body’s own healthy tissues and cells. In these conditions, the body’s defense mechanisms become dysregulated. They are intended to protect against foreign invaders but begin targeting the body’s own components. This results in chronic inflammation and tissue damage.

A key feature of autoimmune diseases is the presence of autoantibodies—antibodies that target the body’s own proteins or structures. These autoantibodies can trigger a cascade of inflammatory responses. This leads to the destruction of healthy tissues. It also leads to the development of various symptoms. Some of the most well-known autoimmune diseases include rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and systemic lupus erythematosus (SLE). In each of these conditions, the immune system attacks specific tissues or organs. This causes a chronic inflammatory state. This state can severely impact health.

For example, in rheumatoid arthritis, the immune system targets the joints, causing inflammation, pain, and potential joint damage. In multiple sclerosis, it attacks the myelin sheath surrounding and insulating the nerves. This attack disrupts neural signal transmission and leads to a range of neurological symptoms.

The exact causes of autoimmune diseases are not fully understood. They likely involve a complex interplay of genetic, environmental, and lifestyle factors. Researchers have identified various genetic markers. They have also found environmental triggers that may contribute to the development of these disorders. These triggers include viral infections, exposure to certain chemicals, and stress.

Treatment for autoimmune diseases typically aims to reduce inflammation and regulate the immune system. This often involves immunosuppressant drugs, anti-inflammatory medications, or targeted biological therapies. Additionally, lifestyle interventions can help manage symptoms. Dietary changes and stress management techniques can slow the progression of these conditions.

The understanding of the underlying mechanisms of autoimmune diseases continues to grow. Researchers are working on developing more effective and personalized treatments. These advancements aim to improve the quality of life for those with chronic inflammatory conditions.

Posted in Understanding the Innate vs. Adaptive Immune System

Understanding the Innate vs. Adaptive Immune System

The innate immune system is the body’s first defense against pathogens and other threats. It consists of various cells, proteins, and mechanisms. They work together to quickly detect and respond to infections and injuries. This process happens without needing prior exposure or specific recognition of the threat.

The innate immune system has a key component. It consists of physical and chemical barriers. These include the skin, mucous membranes, and stomach acid. They prevent the entry of harmful microorganisms. These barriers act as the body’s front line against infection, trapping and neutralizing potential threats before they can cause harm.

Another crucial aspect of the innate immune system involves specialized cells, like macrophages, natural killer cells, and dendritic cells. These cells recognize and respond to the presence of foreign or dangerous substances, triggering a rapid immune response. For example, macrophages can engulf and destroy invading pathogens, while natural killer cells target and remove infected or cancerous cells.

The innate immune system also relies on a complex network of proteins known as the complement system. This system helps to recognize threats. It neutralizes and eliminates them. This system can be activated through various pathways. This activation leads to the destruction of pathogens. It recruits extra immune cells. It also promotes inflammation to clear the infection.

Importantly, the innate immune system does not need prior exposure to a specific pathogen to mount a response. Instead, it recognizes common patterns or molecular signatures linked to various classes of microorganisms, known as pathogen-associated molecular patterns (PAMPs). This allows the innate immune system to respond quickly and effectively to potential threats.

While the innate immune system provides immediate protection, it does not confer long-term, specific immunity. The adaptive immune system comes into action here. It builds on the first response of the innate system. This provides a more targeted and long-lasting defense.

Adaptive Immune System Mechanisms

The adaptive immune system is a specialized and sophisticated part of the body’s overall immune response. It is responsible for developing specific and targeted immunity against particular pathogens or threats. It can generate “memory,” allowing for a stronger and faster response upon subsequent exposures.

The main components of the adaptive immune system are lymphocytes, which include T cells and B cells. These cells recognize and respond to specific antigens—unique molecular markers linked to different pathogens or foreign substances.

T cells play a crucial role in the adaptive immune response. They directly attack and remove infected or cancerous cells. T cells also regulate the overall immune response. There are several types of T cells. Each has a specific function. These include cytotoxic T cells, helper T cells, and regulatory T cells.

B cells, on the other hand, produce antibodies—proteins that can bind to and neutralize specific antigens. When a B cell encounters an antigen it recognizes, it becomes activated. It begins to proliferate. This results in the generation of many plasma cells that secrete antibodies. These antibodies circulate throughout the body, ready to neutralize the targeted pathogen during future exposures.

The adaptive immune system also can “remember” past encounters with pathogens. This ability allows for a rapid and effective response to subsequent infections. This memory is achieved through the generation of memory B and T cells. These cells persist in the body long after the first threat has been eliminated. Upon re-exposure to the same pathogen, these memory cells can quickly become activated. They mount a strong, targeted immune response. This response often prevents the infection from taking hold or reduces its severity.

The adaptability and specificity of the adaptive immune system are key to its effectiveness. They help in defending the body against a wide range of threats. The adaptive immune system builds on the first response of the innate immune system. It provides long-term, pathogen-specific protection. This system plays a vital role in maintaining overall health and well-being.

Interplay between Innate and Adaptive Immunity

The innate and adaptive immune systems work together in a coordinated manner. They complement each other to give comprehensive protection against bodily threats. The two systems have distinct mechanisms and functions. Nonetheless, they are closely intertwined and rely on each other to mount an effective immune response.

The innate immune system acts as the first responder, quickly detecting and responding to potential threats. It acts rapidly to contain and control the early spread of infections. This buys time for the adaptive immune system to engage fully. The innate system plays a key role in activating the adaptive immune response. It releases cytokines and presents antigens to lymphocytes.

In contrast, the adaptive immune system provides more targeted and long-lasting protection. It builds on the foundational work of the innate system. Its recognition and memory capabilities give a tailored and effective response to specific pathogens. This often leads to the elimination or containment of the threat.

The interplay between the innate and adaptive immune systems is particularly clear in the case of vaccination. Vaccines stimulate the adaptive immune system to generate memory cells and antibodies specific to a particular pathogen. But, the innate immune system mediates the first response to the vaccine. It recognizes the vaccine components and triggers an inflammatory response. This response helps start and shape the next adaptive immune response.

Furthermore, the innate and adaptive systems can work together to address different aspects of an immune challenge. For example, the innate system may handle the first detection of a pathogen. It may also be responsible for containment. The adaptive system focuses on long-term elimination. It works on the prevention of future infections.

Researchers and healthcare providers can develop more effective strategies by understanding the interplay between the innate and adaptive immune systems. These strategies help prevent, diagnose, and treat various infectious diseases. They also apply to other immune-related conditions. This knowledge can also inform the development of new vaccines. It can guide therapies and interventions that leverage the unique strengths of innate and adaptive immune systems.

Next up will be Inflammation and the Immune System

Posted in Autoimmune the dis-EASE, The Role of the Immune System, Understanding Autoimmune dis-EASE

Understanding Autoimmune dis-EASE: The Role of the Immune System

The Importance of the Immune System

The immune system is a remarkable network of cells, organs, and processes that protect our bodies from harm. It is our front line defense against viruses, bacteria, parasites, and toxins, ensuring we don’t constantly battle illness.

Its significance goes beyond defense; it recognizes threats, mobilizes resources, and remembers past encounters to strengthen future responses. Understanding its workings helps us appreciate the balance that keeps us healthy.

The immune system is not just a static defense mechanism. It is a dynamic and highly adaptable system. It evolves to face new threats. It regulates inflammation and influences chronic conditions like cancer and autoimmune disorders. By exploring its components and functions, we gain insights into how our immune system interacts with other systems. This exploration leads to exciting advancements in medical research. Let’s celebrate and nurture our immune system for a healthier future!

Components of the Immune System.

The immune system comprises diverse specialized cells, tissues, and organs that work together to defend the body against harmful agents. White blood cells, also known as leukocytes, are at the heart of this intricate network. They are the primary actors in the immune response. Understanding their roles and functions is crucial in comprehending the immune system’s operations. 

There are several key types of white blood cells, each with its unique role and job. Lymphocytes, like T and B cells, recognize and respond to specific threats. Phagocytes, including macrophages and neutrophils, engulf and destroy foreign invaders. Other immune cells, like natural killer and dendritic cells, play crucial roles in the immune response. 

These immune cells are found throughout the body. They circulate in the bloodstream and lymphatic system. They live in specialized organs like the spleen, thymus, and lymph nodes. These organs serve as hubs for immune activity. They offer the necessary infrastructure for the coordination and execution of the body’s defense mechanisms. 

Besides the cellular components, the immune system relies on a complex network of chemical signals and regulatory pathways. Cytokines are signaling molecules. They help orchestrate the immune response. Antibodies are specialized proteins. They neutralize or mark specific threats for destruction. 

We can gain a deeper appreciation for the remarkable ways our bodies work to protect us. We achieve this by understanding the diverse and intricate components of the immune system. This knowledge empowers us to take control of our health. It can enhance our understanding of how the immune system interacts with other physiological systems. This leads to new medical research and treatment avenues. 

Immune System Functions

The immune system is an incredible network of functions vital in protecting our bodies and enhancing our overall health! Its primary mission is to identify and remove potential threats. These threats can disrupt our well-being, like harmful pathogens, abnormal cells, and other foreign invaders.

A fascinating aspect of the immune system is its ability to recognize these dangers. This recognition occurs through a process known as the immune response. When a potential threat is detected, the immune system enthusiastically mobilizes specialized cells and chemicals to combat the intruder. This dynamic response involves various strategies. It activates phagocytes that engulf and remove pathogens. It produces antibodies to mark threats for destruction. Additionally, it recruits more immune cells to strengthen the defense.

Beyond its crucial role in fighting infections and illnesses, the immune system contributes significantly to our general health and vitality. It helps regulate inflammation, a natural reaction to injury or infection. It plays a role in the onset and progression of chronic health conditions like cancer, autoimmune disorders, and cardiovascular diseases.

One of the immune system’s most remarkable abilities is its capacity for learning and memory. This ability helps the body to respond more effectively and target familiar threats. This phenomenon is known as immunological memory. This fascinating ability is the foundation of vaccinations, which harnesses the immune system’s learning to protect against specific diseases.

Exploring our immune system’s diverse and intricate functions can help us better appreciate our body’s efforts. Our bodies work diligently to keep us healthy and secure. This understanding can lead to exciting new medical research. It can also inspire confidence in our journey toward better health.

Up and coming to you soon:

Understanding Autoimmune dis-EASE:

The Role of the Immune System: Autoimmune disorders and immune system dysfunction